WebDec 10, 2024 · Background and objectives: CYP24A1 encodes a 24-hydroxylase involved in vitamin D catabolism, whose loss-of-function results in vitamin D-dependent hypercalcemia. Since the identification of CYP24A1 variants as a cause of idiopathic infantile hypercalcemia, a large body of literature has emerged indicating heterogeneity in … Web细胞色素 P450 24A1(英语:Cytochrome P450 24A1,缩写CYP24A1)也被称为维生素D3 24-羟化酶(Vitamin D3 24-hydroxylase,EC 1.14.15.16),是细胞色素P450超家族的一 …
CYP24A1 - an overview ScienceDirect Topics
WebJan 14, 2015 · 細胞色素 P450 24A1(英語: Cytochrome P450 24A1 ,縮寫CYP24A1)也被稱為維生素D 3 24-羥化酶( Vitamin D3 24-hydroxylase ,EC 1.14.15.16),是細胞 … Web12号染色体开放阅读框4抗体价格公司相关产品: 嗜酸粒趋化蛋白14抗体B Raf(phospho S365) /FITC 荧光素标记兔抗人、大、小鼠磷酸化B-Raf抗体IgG cannot taste coffee
CYP24A1: Structure, Function, and Physiological Role
WebThe physiologic importance of CYP24A1 in the catabolism of 1,25-dihydroxyvitamin D 3 and 25-hydroxyvitamin D 3 has already been shown in CYP24A1 knockout (–/–) mice, which have severe ... CYP24A1 is expressed in tissues which are considered targets for vitamin D, including kidney, intestine and bone. Transcription of the CYP24A1 gene is markedly inducible by 1,25-(OH)2D3 binding to the vitamin D receptor. The gene has a strong, positive vitamin D response element in the promoter. Through regulation of CYP24A1 expression, a negative feedback control system is created to limit the effects of 1,25-(OH)2D3. WebA cytochrome P450 monooxygenase with a key role in vitamin D catabolism and calcium homeostasis. Via C24- and C23-oxidation pathways, catalyzes the inactivation of both the vitamin D precursor calcidiol (25-hydroxyvitamin D 3) and the active hormone calcitriol (1-alpha,25-dihydroxyvitamin D 3) (PubMed:24893882, PubMed:15574355, … cannot tell the difference