Dynein heavy chain 5 axonemal

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WebOct 17, 2006 · PTHR46532:SF13 DYNEIN AXONEMAL HEAVY CHAIN 5 1 hit; PTHR46532 MALE FERTILITY FACTOR KL5 1 hit; Pfam. View protein in Pfam; … WebDec 21, 2024 · NM_001347886.2 → NP_001334815.1 dynein axonemal heavy chain 3 isoform 2. Status: REVIEWED. Description Transcript Variant: This variant (2) represents use of an alternate promoter and therefore differs in the 5' UTR and 5' coding region, compared to variant 1, and also has additional downstream coding region differences. …

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WebOct 10, 2024 · A microarray study conducted by our research group showed alteration in DNAH6 gene (encoding dynein axonemal heavy chain 6). DNAH6 belongs to dynein family, whose members are constituents of the microtubule-associated motor proteins and is downregulated in the striatum of a HD mouse model (knockin Hdh Q111/Q111). In this … WebNov 5, 2024 · RT-PCR assays showed that DNAHC11 was expressed primarily in trachea and testis, 2 tissues containing axonemal structures. Supp et al. (1997) isolated lrd (left-right dynein), the mouse homolog of rat Dlp11. Schwabe et al. (2008) stated that full-length DHAH11 contains 4,523 amino acids. DHAH11 has an N-terminal domain, followed by 4 … hilary golston parents

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WebStreamline supply chains for customization and innovation. Network Service Providers. Address the new commerce and collaboration models that create new sources of growth … WebApr 18, 2024 · These heavy chains of axonemal dyneins so far studied have distinct motile properties in vitro [12,15,16,17,18,19] ... A dynein heavy chain has a molecular mass of typically 500–540 kDa, consisting … WebJul 10, 2024 · we design to provide clues to prove relationship between dynein heavy chain gene 5 (DNAH5) gene alterations and asthenozoospermia. This also provides a reference for patients to choose a reasonable treatment plan or genetic counseling to assist reproductive reproduction. Patients concern: In the present study, we screened 143 … hilary golston wedding

The dynein heavy chain: structure, mechanics and evolution

WebPR:000006564 dynein axonemal heavy chain 5 (term hierarchy) InterPro Domains. IPR003593 AAA+ ATPase domain. IPR026983 Dynein heavy chain. IPR041589 Dynein heavy chain 3, AAA+ lid domain. IPR043157 Dynein heavy chain, AAA1 domain, small subdomain. IPR041466 Dynein heavy chain, AAA 5 extension domain. WebMay 1, 2024 · We identified two rare nonsynonymous variants in the dynein axonemal heavy chain 5 gene (DNAH5): a previously reported variant c.7502G > C; p.(R2501P), and a novel variant c.12043 T > G; p.(Y4015D). Both variants are predicted to be damaging. Ultrastructural analysis of the cilia revealed a lack of outer dynein arms and normal inner … small world wikipediaWebMar 1, 2024 · Figure 1. Organization of axonemal dynein motors. (A) Linear map of a generic ∼4500-residue dynein heavy chain.The amino-terminal region contains two conserved segments found in nearly all these motors: DHC_N1 is involved in heavy-chain assembly, whereas DHC_N2 represents the linker that traverses the plane of the AAA … hilary golston

"Web1 day ago · The beating of motile cilia requires the coordinated action of diverse machineries that include not only the axonemal dynein arms, but also the central apparatus, the radial spokes, and the microtubule inner proteins. ... 2009) and by immunostaining of ODA/IDA heavy chains in vertebrates (Dougherty et al., 2016; Fliegauf et al., 2005; Oltean et ... " - Dynein heavy chain 5 axonemal

Dynein heavy chain 5 axonemal

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WebAug 2, 2024 · Dyneins are microtubule-associated motor protein complexes composed of several heavy, light, and intermediate chains. The dynein heavy chains (DHCs) are … WebMar 29, 2024 · DNAH5 dynein axonemal heavy chain 5 Gene ID: 1767, updated on 29-Mar-2024 Gene type: protein coding Also known as: HL1; PCD; CILD3; KTGNR; …

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WebThe 21S peak, fraction 13, is composed of a-and/5'-heavy chains and IC-1, -2, and -3. ... We present here for the first time a 3D reconstruction of in situ axonemal outer dynein arms. This ... WebEquinix DC5 Ashburn Data Center is located at 21701 Filigree Court, Ashburn, VA, USA. The data center is 92037 sqft. There is a total of 57545 sqft in raised floor space for …

WebDynein heavy chain 7, axonemal, Axonemal beta dynein heavy chain 7, Ciliary dynein heavy chain 7, Dynein heavy chain-like protein 2, hDHC2, DNAH7, KIAA0944: Dilution : Elisa=1:500-1000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC=1:100-500, Format: 0.01M TBS(pH7.4) with 1% BSA, 0.09% (W/V) sodium azide and 50% Glyce: WebDynein heavy chain isoforms and axonemal motility Trends Cell Biol. 1993 Nov;3(11):398-402. doi: 10.1016/0962-8924(93)90090-n. ... of ciliary bends are produced by a precisely located array of different dyneins containing eight or more different dynein heavy chain isoforms. The detailed clarification of the structural and functional diversity ...

WebJul 21, 2004 · The axonemal dynein heavy chain gene Mdnah5 is specifically expressed in ependymal cells, and is essential for ultrastructural and functional integrity of ependymal cilia. In Mdnah5 -mutant mice, lack of ependymal flow causes closure of the aqueduct and subsequent formation of triventricular hydrocephalus during early postnatal brain … WebDescription: Homo sapiens dynein axonemal heavy chain 14 (DNAH14), transcript variant 2, mRNA. (from RefSeq NM_001145154) RefSeq Summary (NM_001145154): Dyneins are microtubule-associated motor protein complexes composed of several heavy, light, and intermediate chains. Two major classes of dyneins, axonemal and cytoplasmic, have …

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WebMar 29, 2024 · This protein is an axonemal heavy chain dynein. It functions as a force-generating protein with ATPase activity, whereby the release of ADP is thought to produce the force-producing power stroke. Mutations in this gene cause primary ciliary dyskinesia type 3, as well as Kartagener syndrome, which are both diseases due to ciliary defects. small world west roxburyWebOct 24, 1997 · Dynein heavy chains are involved in microtubule-dependent transport processes. While cytoplasmic dyneins are involved in chromosome or vesicle movement, … hilary gomesWeb1 day ago · In situ, in the absence of nucleotides, all three heavy chains adopt a Post-2 conformation. ... Each HC of the axonemal dynein consists of an N-terminal tail domain … small world winter sceneWeb1 day ago · In situ, in the absence of nucleotides, all three heavy chains adopt a Post-2 conformation. ... Each HC of the axonemal dynein consists of an N-terminal tail domain followed by the motor domain. This includes six AAA motifs (named AAA1–AAA6), with a microtubule-binding domain (MTBD) connected to AAA4 by a coiled-coil stalk, similar to … small world winter animalsWebCytoplasmic dynein has two identical heavy chains. Flagellar outer arm dyneins have two or three different heavy chains depending on the species. Each flagella has many different inner arm dyneins. Inner arm dynein 1 has two different heavy chains, and there are at least six different inner arm dyneins each with one unique heavy chain. small world wheelchairWebJul 25, 2002 · To date, mutations in two genes have been associated with a minority of PCD/Kartagener syndrome cases. These are genes coding for the dynein axonemal intermediate chain 1 (DNAI1) and the dynein axonemal heavy chain 5 (DNAH5) ().Loss of function of the murine Dnah5 dynein gene also causes PCD in the mouse ().Other … hilary golston husbandWebDynein heavy chain isoforms and axonemal motility Trends Cell Biol. 1993 Nov;3(11):398-402. doi: 10.1016/0962-8924(93)90090-n. ... of ciliary bends are produced by a precisely … hilary grabner counseling