Parafibromin蛋白

Author: nebq

August undefined, 2024

Web结果CDC73 是编码 parafibromin 蛋白的抑癌基因，其突变可能导致 parafibromin 蛋白表达水平降低或缺失。 CDC73 基因突变与甲状旁腺功能亢进症-颌骨肿瘤综合征直接相关， … WebThe Parafibromin protein may be important as a marker for diagnosing parathyroid carcinoma. Parafibromin is encoded by the endocrine tumor suppressor gene CDC73 (cell division cycle 73, Paf1/RNA polymerase II complex component), alternatively known as the HRPT2 (hyperparathyroidism-jaw tumor syndrome 2) gene.

胃肠道癌Parafibromin蛋白的表达及其与临床病理特征和预后的关 …

WebParafibromin is a predominantly nuclear protein with a tumour suppressor role in the development of hereditary and nonhereditary parathyroid carcinomas, and the … Web3.免疫组织化学染色法分析甲状旁腺肿瘤的Parafibromin蛋白或Menin蛋白的表达。 4.临床表型与基因型关系分析。结果 1.在三个家族性孤立性原发性甲状旁腺功能亢进症(familial … synchrony commercial sams club

重组人Parafibromin蛋白(细胞分裂周期蛋白73同源蛋白)(CDC73)

WebParafibromin is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative. Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product. Synonyms: Cdc73, Hrpt2, anti ... WebOct 8, 2004 · Conclusions: Parafibromin is a promising molecular marker for diagnosing parathyroid carcinoma. The similar loss of parafibromin immunoreactivity in HPT-JT syndrome-related adenomas suggests that this is a pivotal step in parathyroid tumorigenesis. INTRODUCTION WebNational Center for Biotechnology Information synchrony company background

Parafibromin-deficient (HPT-JT Type, CDC73 Mutated ... - PubMed

Parafibromin蛋白

WebSep 21, 2024 · In this review, we discuss parafibromin protein, which is encoded by CDC73. A mutation in this gene causes hyperparathyroidism-jaw tumor (HPT-JT) syndrome, an autosomal dominant disease. CDC73 … WebMar 28, 2024 · We conclude that parafibromin immunohistochemistry is a useful marker in the clinical routine when applied on a pre-selected material of cases, with positive …

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WebAbstract The gene CDC73 (previously known as HRPT2) encodes the protein parafibromin. Biallelic mutation of CDC73 is strongly associated with malignancy in parathyroid tumors. Heterozygous germline mutations cause hyperparathyroidism jaw tumor syndrome,which is associated with a high life-time risk of parathyroid carcinoma. WebParafibromin is a protein encoded by the HRPT2 oncosuppressor gene, and the expression is reported to be decreased or absent in parathyroid carcinomas. Parafibromin is expressed in the nucleus of benign parathyroids, parathyroid adenomas, and other normal tissues, but shows loss of expression in parathyroid carcinomas, making it a good ...

Web方法利用自建方法、Ambion和Thermo公司的试剂盒分别提取细胞核蛋白和质蛋白,利用Western blot检测Bag-1、ING5和parafibromin蛋白亚细胞定位,通过选择不同的内参蛋白标记细胞组分蛋白的污染。结果自建核质蛋白提取方法与试剂盒相比,在操作时间和分离效果上无显著差别。发现大小不同Bag-1蛋白在胃癌细胞质和核中定位不同,ING5和parafibromin … WebFeb 10, 2005 · Parafibromin is the 531-amino-acid protein product encoded by HRPT2, a putative tumor suppressor gene recently implicated in the autosomal dominant hyperparathyroidism-jaw tumor familial cancer syndrome, sporadic parathyroid cancer, and a minority of families with isolated hyperparathyroidism.

WebBackground: Parafibromin is a protein encoded by the HRPT2 oncosuppressor gene, and the expression is reported to be decreased or absent in parathyroid carcinomas. Methods: A total of 26 tumor specimens from 18 patients with adenoma and 8 patients with carcinoma were immune-stained with an antibody against parafibromin. http://www.tcsurg.org/article/10.7507/1007-9424.202403046

WebMar 29, 2024 · The parafibromin tumor suppressor protein HRPT2 inhibits cell proliferation by repression of the c-myc proto-oncogene; Parafibromin interacted with muscle alpha-actinins (actinin-2 and actinin-3). inactivating mutations and/or allelic loss of the HRPT2 gene may not play a major role in parathyroid carcinogenesis in secondary HPT due to CKD

WebApr 22, 2024 · CDC73基因突变和(或)parafibromin或CASR蛋白缺失的甲状旁腺癌患者更易复发或转移，生存率较差 [59,60] 。应终生随访患者的复发风险，对于功能性甲状旁腺 … synchrony company in hyderabadWebSep 15, 2015 · Parafibromin plays an important role in IFN-γ–triggered cellular antiviral response. (A) Overexpression of parafibromin inhibits VSV replication. The 293 cells were transfected with a parafibromin plasmid for 18 h and then treated with IFN-γ or left untreated for an additional 12 h. The transfected cells were infected with VSV (multiplicity ... thailand seafood associationWebSep 21, 2024 · In addition, down-regulated parafibromin is closely linked to the tumorigenesis, subsequent progression, or poor prognosis of head and neck, gastric, … synchrony company in bangaloreWeb本试剂盒应用双抗体夹心法测定标本中大鼠肠脂肪酸结合蛋白（i-fabp)水平。用纯化的大鼠肠脂肪酸结合蛋白（i-fabp)抗体包被微孔板，制成固相抗体，往包被单抗的微孔中依次加入肠脂肪酸结合蛋白（i-fabp)，再与hrp标记的肠脂肪酸结合蛋白（i-fabp)抗体结合，形成 ... synchrony companyWebHRPT2基因是一种抑癌基因，其编码的Parafibromin蛋白可与PAF1形成复合体，再通过蛋白-DNA相互作用调控基因转录和翻译，进而诱导细胞凋亡或抑制细胞增殖[3-5]。在人体多 … synchrony company addressWeb产品名称重组人HRPT2/Parafibromin蛋白纯度 > 95 % SDS-PAGE. 内毒素水平 < 1.000 Eu/µg 表达系统 Escherichia coli Accession Q6P1J9 蛋白长度 Protein fragment 无动物成分 No 性质 Recombinant 种属 Human 序列 thailand seafood formalinhttp://www.bjbalb.com/html/Recombinant-Protein/JN0724.html synchrony company hyderabad